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隨著時間推移，細菌進化，開始感染人類，最終演變為鼠疫，它通過跳蚤傳播，在中世紀的歐洲肆虐並造成數百萬人死亡。
鼠疫早期菌株傳播緩慢的觀點，挑戰了許多關於歐洲和亞洲人類文明發展的理論。
而且它對新石器時代末期疾病導致西歐人口大量減少的假說提出了質疑。
其他研究人員對這項研究表示歡迎，但說這項研究並未排除鼠疫於這個時期在歐洲廣泛傳播的可能性。
人類通常是在被攜帶鼠疫細菌的嚙齒類跳蚤咬傷或接觸感染鼠疫的動物後感染鼠疫。
今天，這種疾病仍然存在，但如果及早發現，則可用抗生素治療。
這項研究發表在《細胞報道》（Cell Reports）雜誌上。