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淋巴結屬於人體的淋巴系統，後者又屬於循環系統。淋巴液會在體內循環的過程中收集各種外來物質，在經過淋巴結時，匯聚了很多免疫細胞的淋巴結會起到“過濾”的作用，把諸如細菌、病毒等危險分子清除。當免疫細胞在淋巴結“清理門戶”時，實際上也是發生免疫反應的過程，在這一過程中，免疫細胞會有增殖，有時就在身上表現為淋巴結腫大。
新冠疫苗的作用機理也是誘發人體的免疫反應，注射疫苗誘發的免疫反應一樣會集中在淋巴結，特別是在淋巴循環方向上離注射位置最近的淋巴結。新冠疫苗的接種位置一般是某側上臂肌肉，距離這個接種位置最近的免疫反應中心位置恰好就是注射位置一側的腋下淋巴結。